Actos Heart Failure
One of the most commonly reported Actos side effects is Actos heart failure. In 2007, the FDA issued a safety alert about the diabetes drug, also known as pioglitazone, naming congestive heart failure as one of the most dangerous Actos side effects.
Takeda accused of hiding Actos heart failure numbers
In March 2012, a former medical reviewer for drug manufacturer Takeda accused the company of fraudulently withholding patient reports of Actos heart failure from the FDA. From 2007 to 2010, the company allegedly failed to properly classify hundreds of such cases as serious so as not to impact sales of the drug, which has produced revenues exceeding $500 million per year.
Actos side effects include congestive heart failure
Actos heart failure, or cardiomyopathy, is a condition whereby the heart fails to pump an adequate amount of blood to the body. The more the heart muscles weaken or stiffen, the more circulation decreases. As a result, muscles and organs start to function poorly because they don’t get enough oxygen. As the body begins to shut down, fluid builds up in the tissue, lungs, liver, arms, legs, and gastrointestinal tract.
Cardiomyopathy affects many areas of the body. If the kidneys receive insufficient amounts of blood, they lose their ability to release sodium and water, causing fluid retention. Fluid congestion in the lungs is called pulmonary edema, and can cause difficulty breathing. Meanwhile, fluid build-up in the liver can lead to dangerously high levels of liver toxicity.
Symptoms of Actos heart failure include:
- abnormal, rapid weight gain
- dyspnea (labored breathing, shortness of breath)
- edema (fluid accumulation in the body causing swelling, most commonly in the feet and legs)
- fatigue / weakness
- difficulty lying flat
- impaired exercise capacity
- loss of appetite
- nocturnal urge to urinate
- rapid or otherwise irregular heartbeat
- swollen liver or abdomen
- sleeping problems
Actos heart failure can be treated in multiple ways
Actos heart failure is normally diagnosed with an echocardiogram, or ultrasound. other imaging tests such as heat catheterization, or a heart MRI. In addition, a BNP blood test can be used to test for unusual levels of B-type natriuretic peptids.
Treatments for congestive heart failure may include any of a number of medications, from anti-cholesterol drugs to anticoagulants. Surgeries that may be required include coronary bypass surgery, angioplasty, heart valve surgery, or insertion of a pacemaker. Actos heart failure can also treated with diet and lifestyle changes. Doctors recommend that patients with heart failure restrict alcohol intake, avoid smoking, exercise regularly, and maintain a reasonable weight and cholesterol level. Extreme end-stage heart failure can require an intra-aortic balloon pump, a ventricular assist device, and/or a heart transplant.
FDA asks patients to report Actos side effects
The FDA recommends that any patients who experience Actos side effects, including cardiomyopathy, or Actos bladder cancer should report them to its MedWatch adverse events program.
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